| Insider Name | Buy/Sell | Amount | Shares Change | |||
|---|---|---|---|---|---|---|
| Aug 25, 2014 | Aug 27, 2014 | 5Am Partners Ii, LLC 10% | Sell | $26.51 | $11M | -85.52% |
| Aug 22, 2014 | Aug 26, 2014 | Berman Lance Chief Medical Officer SVP | Sell | $25.89 | $517,722 | -72.73% |
| Aug 15, 2014 | Aug 20, 2014 | Orbimed Advisors LLC 10% | Sell | $26.35 | $26M | -9.96% |
| Aug 11, 2014 | Aug 12, 2014 | Veitinger Klaus R Dr Dir | Sell | $27.73 | $115,563 | -60.58% |
| Aug 08, 2014 | Aug 12, 2014 | Stahl Wilhelm SVP Pharmaceutical Operations | Sell | $25.09 | $1M | -0 |
| Aug 08, 2014 | Aug 12, 2014 | Lockey Claire | Sell | $26.5 | $265,000 | -0 |
| Jul 22, 2014 | Jul 24, 2014 | Berman Lance Chief Medical Officer SVP | Sell | $23.92 | $1M | -0 |
| Jul 10, 2014 | Jul 11, 2014 | Veitinger Klaus R Dr Dir | Sell | $23.12 | $96,354 | -60.58% |
| Nov 20, 2013 | Nov 21, 2013 | New Leaf Ventures I, L.P. Former 10% beneficial owner | Buy | $11 | $2M | +8.08% |
| Nov 20, 2013 | Nov 21, 2013 | Hunt Ronald Former 10% beneficial owner | Buy | $11 | $2M | +8.08% |
| Nov 20, 2013 | Nov 21, 2013 | Silverstein Jonathan Dir 10% | Buy | $11 | $8M | +6.68% |
| Nov 20, 2013 | Nov 21, 2013 | Orbimed Advisors LLC 10% | Buy | $11 | $8M | +6.68% |
| Nov 20, 2013 | Nov 21, 2013 | Rocklage Scott M Dir 10% | Buy | $11 | $103,004 | +13.06% |
| Nov 20, 2013 | Nov 21, 2013 | Rocklage Scott M Dir 10% | Buy | $11 | $4M | +91.95% |
| Nov 20, 2013 | Nov 21, 2013 | 5Am Partners Iii, LLC 10% | Buy | $11 | $4M | +85.67% |
| Nov 20, 2013 | Nov 21, 2013 | Orwin John A Pres CEO | Buy | $11 | $165,000 | +50.00% |