| Insider Name | Buy/Sell | Amount | Shares Change | |||
|---|---|---|---|---|---|---|
| Jun 12, 2015 | Jun 17, 2015 | Torres S. Edward Dir | Sell | $178.99 | $39M | -24.64% |
| May 01, 2015 | May 06, 2015 | Christian Waage SVP GC | Sell | $154.46 | $2M | -0 |
| Feb 27, 2015 | Mar 04, 2015 | Torres S. Edward Dir | Sell | $130.15 | $937,080 | -0.81% |
| Feb 23, 2015 | Feb 26, 2015 | Torres S. Edward Dir | Sell | $129.95 | $3M | -2.87% |
| Feb 20, 2015 | Feb 25, 2015 | Torres S. Edward Dir | Sell | $128.2 | $6M | -4.95% |
| Sep 16, 2014 | Jan 21, 2015 | Christian Waage SVP GC | Sell | $107.05 | $3M | -0 |
| Nov 10, 2014 | Nov 13, 2014 | Boehm Marcus F CTO | Sell | $109.91 | $4M | -21.74% |
| Nov 10, 2014 | Nov 13, 2014 | Peach Robert J Chief Scientific Officer | Sell | $109.74 | $4M | -21.05% |
| Nov 11, 2014 | Nov 13, 2014 | Gujrathi Sheila Chief Medical Officer | Sell | $108.99 | $3M | -19.91% |
| Nov 10, 2014 | Nov 13, 2014 | Hasnain Faheem Pres CEO | Sell | $109.47 | $22M | -34.05% |
| Nov 10, 2014 | Nov 13, 2014 | Mineo Chrysa SVP Corporate Development | Sell | $109.73 | $3M | -22.27% |
| Sep 22, 2014 | Sep 25, 2014 | Torres S. Edward Dir | Sell | $61.36 | $6M | -9.37% |
| Sep 22, 2014 | Sep 25, 2014 | Gujrathi Sheila Chief Medical Officer | Sell | $61.45 | $2M | -16.61% |
| Sep 17, 2014 | Sep 20, 2014 | Torres S. Edward Dir | Sell | $62.76 | $19M | -21.94% |
| Sep 17, 2014 | Sep 19, 2014 | Hinkle David A Sr. Dir. Fin. Controller & CAO | Sell | $64.82 | $129,640 | -0 |
| Sep 16, 2014 | Sep 18, 2014 | Cooper Graham K CFO | Sell | $61.3 | $3M | -0 |
| Sep 02, 2014 | Sep 04, 2014 | Hinkle David A Sr. Dir. Fin. Controller & CAO | Sell | $52.8 | $105,600 | -0 |
| Aug 13, 2014 | Aug 15, 2014 | Torres S. Edward Dir | Sell | $43.24 | $9M | -12.76% |
| Aug 13, 2014 | Aug 15, 2014 | Hinkle David A Sr. Dir. Fin. Controller & CAO | Sell | $42.69 | $128,070 | -0 |
| May 27, 2014 | May 29, 2014 | Burow Kristina Dir | Sell | $29.74 | $5M | -7.39% |
| May 19, 2014 | May 21, 2014 | Torres S. Edward Dir | Sell | $25.26 | $11M | -21.30% |
| May 14, 2014 | May 16, 2014 | Torres S. Edward Dir | Sell | $27.37 | $2M | -4.33% |
| May 13, 2014 | May 15, 2014 | Arch Venture Fund VII LP 10% | Sell | $29.66 | $1M | -2.16% |
| May 13, 2014 | May 15, 2014 | Burow Kristina Dir | Sell | $29.66 | $1M | -2.14% |
| Mar 14, 2014 | Mar 18, 2014 | Mast Erle T Dir | Buy | $50.67 | $15,200 | +50.00% |
| Jan 03, 2014 | Jan 04, 2014 | Rastetter William H Dir | Sell | $30.85 | $1M | -2.28% |
| Jan 02, 2014 | Jan 03, 2014 | Rastetter William H Dir | Sell | $30.29 | $835,428 | -1.66% |
| Dec 06, 2013 | Dec 10, 2013 | Nashat Amir Dir | Sell | $26.7 | $5M | -78.39% |
| Dec 05, 2013 | Dec 07, 2013 | Rastetter William H Dir | Sell | $27.63 | $14M | -23.09% |
| Nov 21, 2013 | Nov 26, 2013 | Rastetter William H Dir | Sell | $22.05 | $6M | -10.35% |