| Insider Name | Buy/Sell | Amount | Shares Change | |||
|---|---|---|---|---|---|---|
| Dec 08, 2017 | Dec 12, 2017 | Hirsch David Dir 10% | Sell | $17.34 | $17M | -30.10% |
| Dec 08, 2017 | Dec 12, 2017 | Longitude Capital Partners, LLC 10% | Sell | $17.34 | $17M | -30.10% |
| Nov 17, 2017 | Nov 21, 2017 | Fleming Alison B CTO | Sell | $17.25 | $79,361 | -15.17% |
| Nov 15, 2017 | Nov 18, 2017 | Heffernan Michael Thomas COB Pres CEO | Sell | $15.53 | $776,500 | -8.21% |
| May 12, 2017 | May 15, 2017 | Brannelly Paul EVP CFO | Buy | $9.18 | $91,800 | +8.32% |
| Aug 12, 2016 | Aug 16, 2016 | Fallon John A. Dir | Buy | $10.59 | $25,151 | +50.00% |
| May 12, 2015 | May 14, 2015 | Longitude Capital Partners, LLC 10% | Buy | $12 | $2M | +5.68% |
| May 12, 2015 | May 14, 2015 | Heron Patrick J Dir 10% | Buy | $12 | $2M | +7.36% |
| May 12, 2015 | May 14, 2015 | Frazier Healthcare Vi, L.P. 10% | Buy | $12 | $2M | +7.36% |
| May 12, 2015 | May 14, 2015 | Tpg Group Holdings (Sbs) Advisors, Inc. Former 10% Owner | Buy | $12 | $1M | +7.02% |
| May 12, 2015 | May 14, 2015 | Skyline Venture Partners V LP 10% | Buy | $12 | $2M | +4.84% |
| May 12, 2015 | May 13, 2015 | Hirsch David Dir 10% | Buy | $12 | $2M | +5.68% |
| May 12, 2015 | May 13, 2015 | Freund John Gordon Dir 10% | Buy | $12 | $2M | +4.84% |