| Insider Name | Buy/Sell | Amount | Shares Change | |||
|---|---|---|---|---|---|---|
| Dec 16, 2015 | Dec 17, 2015 | Aldrich Richard Dir | Sell | $19.76 | $395,190 | -4.43% |
| Dec 14, 2015 | Dec 17, 2015 | Jaeger Wilfred E Dir | Sell | $20.02 | $1M | -0 |
| Dec 14, 2015 | Dec 15, 2015 | McGowan Pauline VP Finance | Sell | $20.07 | $9,997 | -0 |
| Nov 09, 2015 | Nov 10, 2015 | Barrett Ronald W Dir | Sell | $22.27 | $394,152 | -0 |
| Nov 02, 2015 | Nov 03, 2015 | Stuart Nancy COO | Sell | $24.29 | $564,019 | -48.15% |
| Sep 18, 2015 | Sep 22, 2015 | Silverman Robert SVP GC | Sell | $20 | $200,000 | -50.00% |
| Sep 14, 2015 | Sep 15, 2015 | McGowan Pauline VP Finance | Sell | $18.97 | $9,430 | -0 |
| Sep 10, 2015 | Sep 14, 2015 | Jaeger Wilfred E Dir | Sell | $18.22 | $2M | -99.38% |
| Aug 14, 2015 | Aug 18, 2015 | Jaeger Wilfred E Dir | Sell | $15.81 | $12M | -99.73% |
| Aug 13, 2015 | Aug 17, 2015 | Jaeger Wilfred E Dir | Sell | $16.75 | $2M | -90.00% |
| Aug 12, 2015 | Aug 14, 2015 | Jaeger Wilfred E Dir | Sell | $17.49 | $2M | -89.69% |
| Aug 12, 2015 | Aug 14, 2015 | Jaeger Wilfred E Dir | Sell | $14.49 | $1M | -89.69% |
| Jun 12, 2015 | Jun 16, 2015 | McGowan Pauline VP Finance | Sell | $16.08 | $8,009 | -0 |
| Jun 08, 2015 | Jun 10, 2015 | Silverman Robert SVP GC | Sell | $16.35 | $81,758 | -25.00% |
| Mar 13, 2015 | Mar 13, 2015 | McGowan Pauline VP Finance | Sell | $16 | $7,968 | -0 |
| Mar 11, 2015 | Mar 12, 2015 | Silverman Robert SVP GC | Sell | $16 | $80,000 | -20.00% |
| Mar 11, 2015 | Mar 12, 2015 | Stuart Nancy COO | Sell | $15 | $696,450 | -82.28% |
| Mar 11, 2015 | Mar 12, 2015 | McGowan Pauline VP Finance | Sell | $16 | $95,568 | -0 |
| Mar 10, 2015 | Mar 11, 2015 | McGowan Pauline VP Finance | Sell | $13.9 | $307,496 | -0 |
| Nov 18, 2014 | Nov 20, 2014 | Three Arch Management Iv, L.L.C. Dir 10% | Sell | $12.29 | $3M | -95.31% |
| Nov 18, 2014 | Nov 20, 2014 | Three Arch Management III LLC Dir 10% | Sell | $12.29 | $3M | -89.59% |
| Feb 20, 2014 | Feb 21, 2014 | Freund John Gordon Dir 10% | Buy | $14 | $2M | +11.04% |
| Feb 20, 2014 | Feb 21, 2014 | Skyline Venture Partners Qualified Purchaser Fund IV L P 10% | Buy | $14 | $2M | +11.04% |
| Feb 19, 2014 | Feb 21, 2014 | Three Arch Management Iv, L.L.C. Dir 10% | Buy | $14 | $1M | +11.43% |
| Feb 19, 2014 | Feb 21, 2014 | Three Arch Management III LLC Dir 10% | Buy | $14 | $1M | +11.75% |
| Feb 19, 2014 | Feb 21, 2014 | Brookside Capital Management LLC 10% | Buy | $14 | $5M | +18.94% |
| Feb 19, 2014 | Feb 21, 2014 | Qvt Associates Gp LLC 10% | Buy | $14 | $4M | +34.88% |
| Feb 19, 2014 | Feb 20, 2014 | Glaxosmithkline Plc Former 10% Owner | Buy | $14 | $490,000 | +1.29% |
| Feb 19, 2014 | Feb 20, 2014 | Tvm Life Science Ventures VI Gmbh & Co Kg Dir 10% | Buy | $14 | $1M | +5.66% |