| Insider Name | Buy/Sell | Amount | Shares Change | |||
|---|---|---|---|---|---|---|
| Mar 16, 2015 | Mar 17, 2015 | Stamler David A Chief Medical Officer | Sell | $80 | $240,015 | -75.32% |
| Feb 12, 2015 | Feb 17, 2015 | Cmea Ventures VII LP 10% | Sell | $63.08 | $8M | -3.88% |
| Feb 10, 2015 | Feb 17, 2015 | Cmea Ventures VII LP 10% | Sell | $61.34 | $5M | -2.28% |
| Jan 08, 2015 | Feb 17, 2015 | Cmea Ventures VII LP 10% | Sell | $49.13 | $164,287 | -0.10% |
| Feb 09, 2015 | Feb 11, 2015 | Cmea Ventures VII LP 10% | Sell | $61.06 | $5M | -34.52% |
| Feb 04, 2015 | Feb 06, 2015 | Cmea Ventures VII LP 10% | Sell | $59.39 | $6M | -2.79% |
| Jan 28, 2015 | Jan 30, 2015 | Thomas, McNerney & Partners Ii, LLC Dir 10% | Sell | $53.11 | $39M | -13.12% |
| Jan 28, 2015 | Jan 30, 2015 | Zisson Alex Dir | Sell | $53.11 | $39M | -13.12% |
| Jan 28, 2015 | Jan 29, 2015 | Panorama Capital, L.P. 10% | Sell | $53.11 | $14M | -9.75% |
| Jan 28, 2015 | Jan 28, 2015 | Ferguson Rodney A Dir 10% | Sell | $53.11 | $14M | -9.75% |
| Jan 28, 2015 | Jan 28, 2015 | Flynn James E Possible Members of 10% Group 10% | Buy | $56.5 | $85M | +25.21% |
| Dec 22, 2014 | Dec 23, 2014 | Stamler David A Chief Medical Officer | Sell | $53.55 | $142,435 | -73.02% |
| Dec 18, 2014 | Dec 22, 2014 | Cmea Ventures VII LP 10% | Sell | $50.14 | $10M | -5.58% |
| Oct 29, 2014 | Oct 31, 2014 | Cmea Ventures VII LP 10% | Sell | $27.15 | $515,813 | -0.50% |
| Oct 27, 2014 | Oct 29, 2014 | Cmea Ventures VII LP 10% | Sell | $27.02 | $391,799 | -0.38% |
| Oct 23, 2014 | Oct 27, 2014 | Cmea Ventures VII LP 10% | Sell | $26.97 | $444,950 | -0.43% |
| Oct 06, 2014 | Oct 15, 2014 | Cmea Ventures VII LP 10% | Sell | $23.45 | $166,671 | -0.18% |
| Oct 06, 2014 | Oct 08, 2014 | Cmea Ventures VII LP 10% | Sell | $23.45 | $166,671 | -0.18% |
| Feb 10, 2014 | Oct 01, 2014 | Thomas, McNerney & Partners Ii, LLC Dir 10% | Buy | $12 | $989,700 | +1.59% |
| Sep 19, 2014 | Sep 22, 2014 | Proehl Gerald T Dir | Buy | $21.75 | $31,885 | +50.00% |
| May 14, 2014 | Sep 09, 2014 | Zisson Alex Dir 10% | Sell | $20.6 | $255,415 | -0.24% |
| May 14, 2014 | Sep 09, 2014 | Thomas, McNerney & Partners II L.P. 10% | Sell | $20.6 | $255,415 | -0.24% |
| Sep 02, 2014 | Sep 09, 2014 | Cmea Ventures VII LP 10% | Sell | $23.08 | $523,980 | -0.59% |
| Aug 29, 2014 | Sep 09, 2014 | Cmea Ventures VII LP 10% | Sell | $22.59 | $196,552 | -0.22% |
| Aug 27, 2014 | Sep 09, 2014 | Cmea Ventures VII LP 10% | Sell | $22.03 | $652,013 | -0.76% |
| Aug 26, 2014 | Sep 09, 2014 | Cmea Ventures VII LP 10% | Sell | $21.35 | $134,517 | -0.16% |
| Aug 25, 2014 | Sep 09, 2014 | Cmea Ventures VII LP 10% | Sell | $20.81 | $112,358 | -0.14% |
| Aug 22, 2014 | Sep 09, 2014 | Cmea Ventures VII LP 10% | Sell | $20.56 | $34,949 | -0.04% |
| Sep 04, 2014 | Sep 09, 2014 | Cmea Ventures VII LP 10% | Sell | $23.86 | $610,806 | -0.67% |
| Sep 02, 2014 | Sep 04, 2014 | Cmea Ventures VII LP 10% | Sell | $23.08 | $523,980 | -0.59% |
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