| Insider Name | Buy/Sell | Amount | Shares Change | |||
|---|---|---|---|---|---|---|
| May 17, 2017 | Dir | Buy | $39.9 | $39,900 | +7.19% | |
| Apr 20, 2017 | Dir | Buy | $41.7 | $83,400 | +14.39% | |
| Feb 16, 2017 |
| Duyk Geoffrey M Dir |
| Sell |
| $46.63 |
| $2M |
| -92.44% |
| Oct 06, 2016 | Oct 11, 2016 | Foresite Capital Management Ii, LLC 10% | Sell | $40.34 | $2M | -2.90% |
| Oct 06, 2016 | Oct 08, 2016 | Foresite Capital Management Ii, LLC 10% | Sell | $40.34 | $2M | -2.90% |
| Jul 22, 2016 | Jul 26, 2016 | Foresite Capital Management Ii, LLC 10% | Buy | $17.5 | $4M | +6.90% |
| Feb 04, 2015 | Apr 26, 2016 | Cagle Gerald D. Dir | Buy | $18.24 | $84,766 | +36.17% |
| Apr 14, 2015 | Apr 16, 2015 | Mehra Anand Dir | Sell | $33.64 | $14M | -47.51% |
| Oct 25, 2013 | Jan 30, 2015 | Clarus Lifesciences Ii, L.P. 10% | Buy | $10 | $3M | +8.47% |
| Jan 08, 2015 | Jan 12, 2015 | Clarus Lifesciences Ii, L.P. 10% | Sell | $31.11 | $5M | -5.00% |
| Jan 05, 2015 | Jan 06, 2015 | Clarus Lifesciences Ii, L.P. 10% | Sell | $30.86 | $728,913 | -0.67% |
| Dec 26, 2014 | Dec 30, 2014 | Clarus Lifesciences Ii, L.P. 10% | Sell | $30.05 | $2M | -2.24% |
| Dec 22, 2014 | Dec 24, 2014 | Clarus Lifesciences Ii, L.P. 10% | Sell | $30.36 | $2M | -1.36% |
| Nov 25, 2014 | Nov 26, 2014 | Tpg Group Holdings (Sbs) Advisors, Inc. Former 10% Owner (2)(3)(4) | Sell | $25.97 | $34M | -38.38% |
| Nov 25, 2014 | Nov 26, 2014 | Mehra Anand Dir | Sell | $26 | $21M | -51.06% |
| Jul 09, 2014 | Jul 12, 2014 | Mehra Anand 10% | Sell | $24.02 | $24M | -0 |
| Jul 09, 2014 | Jul 12, 2014 | Sofinnova Venture Partners VII L P 10% | Sell | $24.02 | $24M | -0 |
| Jul 09, 2014 | Jul 11, 2014 | Tpg Group Holdings (Sbs) Advisors, Inc. 10% | Sell | $25.17 | $25M | -22.79% |
| May 22, 2014 | May 27, 2014 | Mehra Anand Dir 10% | Sell | $16 | $5M | -10.48% |
| May 22, 2014 | May 27, 2014 | Acp Iv, L.P. 10% | Sell | $16 | $5M | -7.66% |
| May 16, 2014 | May 20, 2014 | Cagle Gerald D. Dir | Buy | $15.07 | $27,940 | +50.00% |
| Oct 30, 2013 | Nov 01, 2013 | Acp Iv, L.P. 10% | Buy | $10 | $1M | +2.73% |
| Oct 30, 2013 | Nov 01, 2013 | Levy Brian Chief Medical Officer | Buy | $10 | $60,000 | +50.00% |
| Oct 30, 2013 | Nov 01, 2013 | Mitro Thomas A Pres COO | Buy | $10 | $50,000 | +50.00% |
| Oct 30, 2013 | Nov 01, 2013 | Anido Vicente Jr CEO | Buy | $10 | $280,000 | +50.00% |
| Oct 30, 2013 | Nov 01, 2013 | Rubino Richard J CFO | Buy | $10 | $100,000 | +2.56% |
| Oct 30, 2013 | Nov 01, 2013 | Tpg Group Holdings (Sbs) Advisors, Inc. 10% | Buy | ~ | $0 | +6.08% |
| Oct 25, 2013 | Oct 30, 2013 | Mehra Anand Dir 10% | Buy | $10 | $3M | +8.44% |
| Oct 25, 2013 | Oct 28, 2013 | Clarus Lifesciences Ii, L.P. 10% | Buy | $10 | $3M | +8.08% |