| Insider Name | Buy/Sell | Amount | Shares Change | |||
|---|---|---|---|---|---|---|
| May 04, 2015 | May 06, 2015 | Hull Hans SVP Business Operations | Sell | $30.87 | $154,349 | -30.64% |
| May 04, 2015 | May 06, 2015 | Bain Linda CFO | Sell | $31.59 | $78,972 | -21.74% |
| May 04, 2015 | May 06, 2015 | Wachter Paul Dir | Sell | $30.87 | $36,797 | -2.51% |
| May 01, 2015 | May 05, 2015 | Blumenkranz Mark S. Dir | Sell | $32.37 | $647,306 | -3.16% |
| Apr 28, 2015 | Apr 30, 2015 | Gasmi Mehdi VP Pharmaceutical Development | Sell | $35.67 | $35,667 | -12.50% |
| Apr 27, 2015 | Apr 29, 2015 | Wachter Paul Dir | Sell | $35.61 | $42,443 | -2.45% |
| Apr 23, 2015 | Apr 23, 2015 | Schwartz Steven Daniel Dir | Sell | $38.62 | $651,665 | -3.72% |
| Apr 21, 2015 | Apr 23, 2015 | Gasmi Mehdi VP Pharmaceutical Development | Sell | $39.21 | $39,211 | -12.50% |
| Apr 20, 2015 | Apr 21, 2015 | Wachter Paul Dir | Sell | $40.19 | $47,910 | -2.49% |
| Apr 16, 2015 | Apr 20, 2015 | Blumenkranz Mark S. Dir | Sell | $41.59 | $1M | -3.81% |
| Apr 13, 2015 | Apr 15, 2015 | Zygtech, LLC 10% | Sell | $39.55 | $988,672 | -1.01% |
| Apr 13, 2015 | Apr 15, 2015 | Wachter Paul Dir | Sell | $39.34 | $46,896 | -2.43% |
| Apr 14, 2015 | Apr 15, 2015 | Gasmi Mehdi VP Pharmaceutical Development | Sell | $39.45 | $39,448 | -0 |
| Apr 09, 2015 | Apr 13, 2015 | Schwartz Steven Daniel Dir | Sell | $39.73 | $685,278 | -3.68% |
| Apr 07, 2015 | Apr 08, 2015 | Blumenkranz Mark S. Dir | Sell | $38.72 | $1M | -4.24% |
| Apr 07, 2015 | Apr 08, 2015 | Hull Hans SVP Business Operations | Sell | $38.6 | $1M | -89.23% |
| Apr 07, 2015 | Apr 08, 2015 | Gasmi Mehdi VP Pharmaceutical Development | Sell | $38.6 | $347,425 | -0 |
| Jan 13, 2015 | Jan 15, 2015 | Zygtech, LLC 10% | Sell | $55.46 | $6M | -3.90% |
| Jan 13, 2015 | Jan 15, 2015 | Wachter Paul Dir | Sell | $55.46 | $776,440 | -22.19% |
| Jan 13, 2015 | Jan 15, 2015 | Schwartz Steven Daniel Dir | Sell | $55.46 | $5M | -16.27% |
| Jan 13, 2015 | Jan 15, 2015 | Chalberg Thomas W. CEO | Sell | $55.46 | $5M | -7.02% |
| Jan 13, 2015 | Jan 15, 2015 | Blumenkranz Mark S. Dir | Sell | $55.46 | $6M | -12.76% |
| Aug 05, 2014 | Aug 07, 2014 | Venrock Healthcare Capital Partners Ii, L.P. 10% | Buy | $17 | $7M | +14.46% |
| Aug 05, 2014 | Aug 07, 2014 | Venrock Associates Vi, L.P. 10% | Buy | $17 | $7M | +14.46% |
| Aug 05, 2014 | Aug 05, 2014 | Regeneron Pharmaceuticals Inc 10% | Buy | $17 | $10M | +24.54% |
| Aug 05, 2014 | Aug 05, 2014 | Flynn James E Possible Members of 10% Group 10% | Buy | $23.92 | $32M | +37.78% |