| Insider Name | Buy/Sell | Amount | Shares Change | |||
|---|---|---|---|---|---|---|
| Dec 28, 2015 | Dec 30, 2015 | Alta Partners Viii, L.P. Former 10% Owner | Sell | $1.51 | $1M | -37.33% |
| Dec 17, 2015 | Dec 21, 2015 | Locke Kenneth W Chief Scientific Officer | Sell | $1.26 | $753 | -0 |
| Dec 17, 2015 | Dec 21, 2015 | Knudson Susan A. CFO | Sell | $1.26 | $1,266 | -0 |
| Dec 15, 2015 | Dec 17, 2015 | Alta Partners Viii, L.P. 10% | Sell | $1.44 | $762,136 | -19.84% |
| Nov 18, 2015 | Nov 20, 2015 | Locke Kenneth W Chief Scientific Officer | Sell | $8.3 | $50,619 | -95.42% |
| Sep 18, 2015 | Sep 22, 2015 | Kemmerer Christopher VP Pharma Dev Manufacturing | Sell | $12.2 | $12,195 | -8.44% |
| Sep 01, 2015 | Sep 03, 2015 | Knudson Susan A. CFO | Sell | $11.33 | $33,990 | -85.91% |
| Aug 07, 2015 | Aug 10, 2015 | Kemmerer Christopher VP Pharma Dev Manufacturing | Sell | $12.88 | $12,880 | -8.44% |
| Mar 19, 2015 | Mar 20, 2015 | Mahaffey George W Pres CEO | Buy | $7.76 | $7,757 | +0.50% |
| Nov 25, 2014 | Dec 10, 2014 | Domain Parters VII L P 10% | Buy | $14 | $980,000 | +2.21% |
| Nov 25, 2014 | Nov 26, 2014 | Domain Parters VII L P 10% | Buy | $14 | $980,000 | +2.21% |
| Nov 25, 2014 | Nov 26, 2014 | Rmi Investments S.A.R.L. 10% | Buy | $14 | $980,000 | +4.23% |
| Nov 25, 2014 | Nov 26, 2014 | Gorbachev Maxim Dir 10% | Buy | $14 | $980,000 | +4.23% |
| Nov 25, 2014 | Nov 26, 2014 | Janney Daniel Dir 10% | Sell | $14 | $2M | -5.30% |